WebSep 14, 2024 · The JAX Diversity Outbred (J:DO) mice, for example, is a unique platform to test therapeutic interventions in a population that models the diversity seen in a human population. The JAX Diversity Mouse Portfolio. Here, we present the JAX Diversity Mouse Portfolio. These diversity models were generated with different breeding strategies, … WebAug 17, 2024 · Author summary More humans die of tuberculosis (TB) than any other infectious disease, yet diagnostic tools remain limited. Here, we used the Diversity Outbred mouse population to discover candidate protein biomarkers of human TB. By applying statistical methods and machine learning to multidimensional data, we identified CXCL1 …
(PDF) The Diversity Outbred Mouse Population
WebDiversity Outbred (J:DO) mice are a population of outbred animals with well-randomized genetic sequence polymorphisms and a genetic architecture similar to that of human populations. This study was designed to evaluate baseline characteristics of J:DO mice that could serve as a foundation for future toxicological studies using this population ... WebThe JAX Diversity Outbred (J:DO) mice, for example, is a unique platform to test therapeutic interventions in a population that models the diversity seen in a human population. The JAX Diversity Mouse Portfolio. Here, we present the JAX Diversity Mouse Portfolio. These diversity models were generated with different breeding strategies, … hoover steam vac power scrub
Mouse phenome database - PubMed
WebJan 25, 2024 · It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Inte … WebAug 15, 2012 · The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous DO mice display ... Webtumor, Wei lab established a novel gene discovery platform of Diversity Outbred (DO) F1 mice that express HER2/Neu oncogene. Each mouse carries individually unique genetic composition that enables high-resolution linkage between genotype and phenotype. Using this platform, regulatory genes of tumor progression and vaccine response have been hoover steam vac repairs