WebAug 1, 2007 · CYP3A4: Unplanned pregnancy caused by reduced estradiol level 20: Clarithromycin (Biaxin), erythromycin, telithromycin (Ketek) CYP3A4 inhibitor: … WebJan 1, 2013 · Both erythromycin and clarithromycin decreased the activity of CYP3A4 in a time-dependent manner. The maximum inactivation rate constants, κ inact, max , of erythromycin for CYP3A4.2 and CYP3A4.7 were 0.5-fold that for CYP3A4.1, while that for CYP3A4.16 and CYP3A4.18 were similar to that for CYP3A4.1.
CYP3A4 - an overview ScienceDirect Topics
WebSep 1, 2024 · Do not use erythromycin concomitantly with HMG CoA reductase inhibitors (statins) that are extensively metabolized by CYP3A4 (lovastatin or simvastatin), due to the increased risk of myopathy, including rhabdomyolysis. Warnings Hepatotoxicity WebApr 1, 2003 · Erythromycin is a potent inhibitor of CYP3A4 that markedly increases circulating levels of some other HMG-CoA reductase inhibitors. Methods In this randomised, double-blind, two-way cross-over, placebo-controlled trial 14 healthy volunteers were given 500 mg erythromycin or placebo four times daily for 7 days. the ultimate guide to field photography book
In vitro interactions of abiraterone, erythromycin, and …
WebDec 16, 2015 · Many drugs that are CYP3A4 substrates, inhibitors, and inducers are also inhibitors or inducers of the ABC transport protein known as P-glycoprotein. Many drug interactions, therefore, involve additive effects of both CYP3A4 and P-glycoprotein. Table 1: CYP3A4 Substratesa Alfentanil (Alfenta) Alfuzosin (Uroxatral) Almotriptan (Axert) Web- Gleichzeitige Anwendung von Arzneimitteln, die starke Induktoren von CYP3A4 sind (z. B. Carbamazepin). 4.4 Besondere Warnhinweise und Vorsichtsmaßnahmen für die Anwendung Es liegen keine Daten vor zur Behandlung mit Delamanid über mehr als 24 aufeinanderfolgende Wochen (siehe Abschnitt 4.2). Web临床药理学临床药理学 (1).pdf,Cancer Treatment Reviews 74 (2024) 21–28 Contentslistsavailableat ScienceDirect CancerTreatmentReviews journal homepage ... the ultimate guide to digital photography pdf