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Pdgfra-creert2

Splet04. sep. 2024 · This differs from the results from a recent lineage tracing study using a Pdgfra-CreERT2 BAC transgenic line, which showed that lineaged cells gave rise to more lipofibroblasts than myofibroblasts at the same stage (P7) (Ntokou et al., 2015). The difference of the results may be due to differences in the cell populations that are … Splet01. apr. 2024 · TL;DR: Results demonstrate that autophagy is an important mechanism related to Klfs in smooth muscle cells during AAA formation, and Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagic genes in smooth Muscle cells following elastase treatment. Abstract: …

PDGFRA/NG2 glia generate myelinating oligodendrocytes and

Splet23. apr. 2014 · The discovery of stem and progenitor cells in the adult mammalian heart has added a vital dimension to the field of cardiac regeneration. Cardiac-resident stem cells are likely sequestered as reserve cells within myocardial niches during the course of embryonic cardiogenesis, although they may also be recruited from external sources, such as bone … Splet15. mar. 2024 · Fosl2tg; Pdgfra-CreERT2; tdTomatoflox, Fosl2tg; Acta2-CreERT2; tdTomatoflox, and littermate controls were eutha-nized, and lungs harvested at 20 wk of … breakwater\\u0027s yb https://kathyewarner.com

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Splet22. mar. 2024 · Postnatal deletion of the Igf1r gene impairs alveolarization. Constitutive deletion of the mouse Igf1r gene caused respiratory failure following birth ().Since the deletion of Igf1r with an epithelial-specific Nkx2-1-Cre did not alter lung morphogenesis (), we tested whether its conditional deletion in lung fibroblasts influenced postnatal lung … Splet08. okt. 2008 · About 4% of the cells in the adult rodent brain are PDGFRA+ NG2+ glia, derived from the oligodendrocyte lineage. Rivers and colleagues constructed a transgenic mouse to fate map the PDGFRA+ glia. SpletIn this line of Pdgfra-CreERT2 mice, both Pdgfra mRNA (c) and Cre mRNA (d) were found in cells scattered through the brain, as expected for PDGFRA-positive OLPs (c and d are … breakwater\u0027s y4

PDGFRA - Wikipedia

Category:Pdgfra marks a cellular lineage with distinct contributions to

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Pdgfra-creert2

032770 - Pdgfrα-CreER[T2] Strain Details - The Jackson …

Splet01. okt. 2024 · 1 Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.. 2 Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.. 3 Department of Vascular Surgery, DeBakey Heart and Vascular … SpletA TdTomato-expressing cell (red, arrow) migrates along a vessel (green, outlined by dotted line) at the edge of a 1.5-dpl lesion (Supplementary Video 1). e, Frequency of PDGFRα⁺ OPC clusters at ...

Pdgfra-creert2

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SpletSham and overloaded mesenchymal progenitors from Control (Pdgfra-CreERT2) or cdKO (Pdgfra-CreERT2::Yap1 flox/flox ::Taz flox/flox) were used for RNA-seq analysis. Contributor(s) Kaneshige A, Kaji T, Yasuyuki O, Fukada S: Citation(s) 34856120: Submission date: Dec 08, 2024: Last update date: Feb 18, 2024: Splet01. dec. 2010 · We administered tamoxifen to Pdgfra-CreERT2:Rosa26R-YFP mice to induce yellow fluorescent protein (YFP) expression in PDGFRA/NG2 cells and their differentiated progeny. We subsequently induced EAE and observed a large (>4-fold) increase in the local density of YFP+ cells, >90% of which were oligodendrocyte lineage …

Splet21. jul. 2024 · 如果不知道来源，可以尝试从引物的序列入手。. 先通过blast来查找引物所配对的序列来源，然后逆推转基因的设计。. Pdgfra-creER 转基因小鼠 是由Pdgf receptor a … Splet07. feb. 2024 · Summary. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens …

SpletNational Center for Biotechnology Information Splet03. okt. 2024 · Disclosed are methods and compositions for treating cardiovascular diseases including cardiomyopathy and heart failure. Particularly disclosed are methods and compositions that utilize or comprise inhibitors of hypoxia-inducible factor (HIF)-2α or agonists/inducers of HIF prolyl hydroxylase domain-2 (PHD2) signaling for treating …

Splet07. dec. 2015 · In the present study, the Pdgfra gene was systemically inactivated in adult mouse (α-KO mouse) and the role of PDGFRα was examined in the subcutaneously …

Splet06. apr. 2024 · (A) Whole-mount images of SI from Pdgfra CreERT2;R26R mT/mG mice, where Cre-expressing cells convert ubiquitous tdTom fluorescence (red) to eGFP signal (green), counterstained for F-actin (phalloidin, white). 30 μm z stack overlay. The dashed box is enlarged to the right and the crypt in that image is marked with a dashed white line. breakwater\\u0027s yqSplet24. maj 2016 · By conditionally knocking out the transcription factor Myelin regulatory factor (Myrf) in OPs, using a tamoxifen-inducible Pdgfra-CreERT2 transgene, we were able to show that blocking production of new oligodendrocytes post-tamoxifen impaired the animals’ ability to learn a motor skill (running on wheels with unevenly spaced rungs), … cost of titling a car in missouriSpletStrain #: 018280. RRID:IMSR_JAX:018280. Pdgfra-creERTM transgenic mice can be used to create conditional mutations in oligodendrocyte precursor or NG2 + cells in the adult … breakwater\u0027s yrSpletPatients with CEL and PDGFRA rearrangement may demonstrate systemic symptoms such as pruritis, restrictive cardiomyopathy (due to endomyocardial fibrosis), pulmonary … breakwater valuation servicesSpletThe data suggest that Pdgfrα-CreERT2 transgenic mice can be used to achieve robust recombination in OPCs, while having a minimal effect on most PDGFRα+ cell populations outside of the CNS. In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells … cost of tito\u0027s handmade vodkaSplet032770 B6.129S- Pdgfra tm1.1(cre/ERT2)Blh /J Pdgfrα-CreER T2 mice have a cre/ERT2 fusion gene inserted into the start codon of the platelet derived growth factor receptor, … breakwater\\u0027s ycSpletN1 - Funding Information: We thank D. Bergles (Johns Hopkins School of Medicine) for providing NG2DsRed and Pdgfra-creERT2 mice, M. Turmaine for assistance with electron microscopy, and L.-J. Chew for comments on the manuscript. breakwater\u0027s yc